Article
Genome-wide association studies in asthma; perhaps, the end of the beginning.
Current opinion in allergy and clinical immunology - 1 Oct 2013
Lockett Gabrielle A, Holloway John W
Abstract excerpt
PURPOSE OF REVIEW: A large number of genetic loci contribute towards an individual's susceptibility to asthma and other complex diseases. Genome-wide association studies (GWASs) have provided us with a wealth of loci associated with asthma susceptibility, asthma endotypes and responsiveness to asthma medications. The reproducibility of these genetic loci across different studies highlights the interplay of...
Topics
- Animals
- Asthma
- Genetic Loci
- Genetic Predisposition to Disease
- Genome-Wide Association Study
- Humans
- Phenotype
- Polymorphism, Single Nucleotide
- Reproducibility of Results