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Article

IMPACT: a whole-exome sequencing analysis pipeline for integrating molecular profiles with actionable therapeutics in clinical samples.

Journal of the American Medical Informatics Association : JAMIA - 1 Jul 2016

Hintzsche Jennifer, Kim Jihye, Yadav Vinod, Amato Carol, Robinson Steven E, Seelenfreund Eric, Shellman Yiqun, Wisell Joshua, Applegate Allison, McCarter Martin, Box Neil, Tentler John, De Subhajyoti, Robinson William A, Tan Aik Choon

Abstract excerpt

OBJECTIVE: Currently, there is a disconnect between finding a patient's relevant molecular profile and predicting actionable therapeutics. Here we develop and implement the Integrating Molecular Profiles with Actionable Therapeutics (IMPACT) analysis pipeline, linking variants detected from whole-exome sequencing (WES) to actionable therapeutics. METHODS AND MATERIALS: The IMPACT pipeline contains 4 analytical...

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Source

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Identifiers

PMID: 27026619
DOI: 10.1093/jamia/ocw022
PMCID: PMC4926746

Genes

IMPACT
EGFR
BRAF
NRAS

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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