Article
Clinical actionability enhanced through deep targeted sequencing of solid tumors.
Clinical chemistry - 1 Mar 2015
Chen Ken, Meric-Bernstam Funda, Zhao Hao, Zhang Qingxiu, Ezzeddine Nader, Tang Lin-Ya, Qi Yuan, Mao Yong, Chen Tenghui, Chong Zechen, Zhou Wanding, Zheng Xiaofeng, Johnson Amber, Aldape Kenneth D, Routbort Mark J, Luthra Rajyalakshmi, Kopetz Scott, Davies Michael A, de Groot John, Moulder Stacy, Vinod Ravi, Farhangfar Carol J, Shaw Kenna Mills, Mendelsohn John, Mills Gordon B, Eterovic Agda Karina
Abstract excerpt
BACKGROUND: Further advances of targeted cancer therapy require comprehensive in-depth profiling of somatic mutations that are present in subpopulations of tumor cells in a clinical tumor sample. However, it is unclear to what extent such intratumor heterogeneity is present and whether it may affect clinical decision-making. To study this question, we established a deep targeted sequencing platform to identify...
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