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Article

MYBPC3 mutations are associated with a reduced super-relaxed state in patients with hypertrophic cardiomyopathy.

PloS one - 1 Jan 2017

McNamara James W, Li Amy, Lal Sean, Bos J Martijn, Harris Samantha P, van der Velden Jolanda, Ackerman Michael J, Cooke Roger, Dos Remedios Cristobal G

Abstract excerpt

The "super-relaxed state" (SRX) of myosin represents a 'reserve' of motors in the heart. Myosin heads in the SRX are bound to the thick filament and have a very low ATPase rate. Changes in the SRX are likely to modulate cardiac contractility. We previously demonstrated that the SRX is significantly reduced in mouse cardiomyocytes lacking cardiac myosin binding protein-C (cMyBP-C). Here, we report the effect of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 28658286
DOI: 10.1371/journal.pone.0180064
PMCID: PMC5489194

Genes

MYBPC3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

MYBPC3 mutations are associated with a reduced super-relaxed state in patients with hypertrophic cardiomyopathy.PMID 28658286Read ↗

Ablation of cardiac myosin binding protein-C disrupts the super-relaxed state of myosin in murine cardiomyocytes.Semantic proximity Read ↗

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<i>MYBPC3</i> Mutations cause Hypertrophic Cardiomyopathy by Dysregulating Myosin: Implications for TherapySemantic proximity Read ↗

Haploinsufficiency of MYBPC3 exacerbates the development of hypertrophic cardiomyopathy in heterozygous mice.Semantic proximity Read ↗

The Role of Cardiac Myosin Binding Protein C3 in Hypertrophic Cardiomyopathy-Progress and Novel Therapeutic Opportunities.Semantic proximity Read ↗

Contractile dysfunction irrespective of the mutant protein in human hypertrophic cardiomyopathy with normal systolic function.Semantic proximity Read ↗

Preserved cross-bridge kinetics in human hypertrophic cardiomyopathy patients with MYBPC3 mutations.Semantic proximity Read ↗

Contractile dysfunction in a mouse model expressing a heterozygous MYBPC3 mutation associated with hypertrophic cardiomyopathy.Semantic proximity Read ↗

A hypertrophic cardiomyopathy-associated MYBPC3 mutation common in populations of South Asian descent causes contractile dysfunction.Semantic proximity Read ↗

<i>MYBPC3</i> D389V Variant Induces Hypercontractility in Cardiac OrganoidsSemantic proximity Read ↗

Cardiac myosin-binding protein C: hypertrophic cardiomyopathy mutations and structure-function relationships.Semantic proximity Read ↗

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