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Article

Apolipoprotein E ε4 genotype status is not associated with neuroimaging outcomes in a large cohort of HIV+ individuals.

Journal of neurovirology - 1 Oct 2016

Cooley Sarah A, Paul Robert H, Fennema-Notestine Christine, Morgan Erin E, Vaida Florin, Deng Qianqian, Chen Jie Ashley, Letendre Scott, Ellis Ronald, Clifford David B, Marra Christina M, Collier Ann C, Gelman Benjamin B, McArthur Justin C, McCutchan J Allen, Simpson David M, Morgello Susan, Grant Igor, Ances Beau M

Abstract excerpt

Previous neuroimaging studies suggest a negative relationship between the apolipoprotein (ApoE) ε4 allele and brain integrity in human immunodeficiency virus (HIV)-infected (HIV+) individuals, although the presence of this relationship across adulthood remains unclear. The purpose of this study is to clarify the discrepancies using a large, diverse group of HIV+ individuals and multiple imaging modalities...

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Identifiers

PMID: 27021072
DOI: 10.1007/s13365-016-0434-7
PMCID: PMC5040614

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