Article
APOE ε 4 allele and CSF APOE on cognition in HIV-infected subjects.
Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology - 1 Sept 2011
Andres Marilou A, Feger Ute, Nath Avindra, Munsaka Sody, Jiang Caroline S, Chang Linda
Abstract excerpt
The significance of the cerebrospinal fluid (CSF) Apolipoprotein E (APOE) level and whether it might have differential effects on brain function due to the presence of APOE ε 4 allele(s) in HIV-infected patients are unknown. However, APOE ε 4 allele has been associated with greater incidence of HIV-associated dementia and accelerated progression of HIV infection. Here, we show further evidence for the role of...
Topics
- AIDS Dementia Complex
- Alleles
- Apolipoprotein E4
- Apolipoproteins E
- Cognition
- Enzyme-Linked Immunosorbent Assay
- Female
- Genetic Predisposition to Disease
- Genotype
- Humans
- Male
- Middle Aged
- Neuropsychological Tests
- Protein Isoforms