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Loss of Kynurenine 3-Mono-oxygenase Causes Proteinuria

28 Mar 2016

Abstract excerpt

Changes in metabolite levels of the kynurenine pathway have been observed in patients with CKD, suggesting involvement of this pathway in disease pathogenesis. Our recent genetic analysis in the mouse identified the kynurenine 3-mono-oxygenase (KMO) gene (Kmo) as a candidate gene associated with albuminuria. This study investigated this association in more detail. We compared KMO abundance in the glomeruli of...

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PMID: 27020856
DOI: 10.1681/asn.2015070835

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