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Epigenetics of Aging

29 Aug 2015

Abstract excerpt

The best-known phenomenon exemplifying epigenetic drift (the alteration of epigenetic patterns during aging) is the gradual decrease of global DNA methylation. Aging cells, different tissue types, as well as a variety of human diseases possess their own distinct DNA methylation profiles, although the functional impact of these is not always clear. DNA methylation appears to be a dynamic tool of transcriptional...

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PMID: 27019618
DOI: 10.2174/1389202916666150817203459

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