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Article

Revisiting multiple models of progression of β-cell loss of function in type 1 diabetes: Significance for prevention and cure.

Journal of diabetes - 1 Jul 2016

Li Xia, Cheng Jin, Zhou Zhiguang

Abstract excerpt

Type 1 diabetes (T1D) results from a chronic autoimmune process that leads to β-cell destruction and exogenous insulin dependence. The natural history of T1D proposed by Eisenbarth suggested six relatively independent stages over the course of the entire disease process, which was considered to be linear and chronic. Based on this classical theory, immunotherapies aim to prevent or reverse all these periods of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 26754489
DOI: 10.1111/1753-0407.12376

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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