Internalization of tau antibody and pathological tau protein detected with a flow cytometry multiplexing approach

Abstract excerpt

Abstract Introduction Tau immunotherapy has emerged as a promising approach to clear tau aggregates from the brain. Our previous findings suggest that tau antibodies may act outside and within neurons to promote such clearance. Methods We have developed an approach using flow cytometry, a human neuroblastoma cell model overexpressing tau with the P301L mutation, and paired helical filament (PHF)–enriched...

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