Addition of chromosomal microarray and next generation sequencing to FISH and classical cytogenetics enhances genomic profiling of myeloid malignancies.

doi:10.1016/j.cancergen.2017.07.010

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Article

Addition of chromosomal microarray and next generation sequencing to FISH and classical cytogenetics enhances genomic profiling of myeloid malignancies.

Cancer genetics - 1 Oct 2017

Mukherjee Sandeep, Sathanoori Malini, Ma Zeq, Andreatta Matthew, Lennon Patrick A, Wheeler Scott R, Prescott James L, Coldren Christopher, Casey Terence, Rietz Heather, Fasig Kristina, Woodford Randall, Hartley Taylor, Spence David, Donnelan William, Berdeja Jesus, Flinn Ian, Kozyr Natalia, Bouzyk Mark, Correll Mick, Ho Hao, Kravtsov Vladimir, Tunnel Dana, Chandra Pranil

Abstract excerpt

Comprehensive genetic profiling is increasingly important for the clinical workup of hematologic tumors, as specific alterations are now linked to diagnostic characterization, prognostic stratification and therapy selection. To characterize relevant genetic and genomic alterations in myeloid malignancies maximally, we utilized a comprehensive strategy spanning fluorescence in situ hybridization (FISH), classical...

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PMID: 29025587
DOI: 10.1016/j.cancergen.2017.07.010

Genes

APC
ATM
RUNX1
SRSF2
TET2

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