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Article

Computational Modeling of PI3K/AKT and MAPK Signaling Pathways in Melanoma Cancer.

PloS one - 1 Jan 2016

Pappalardo Francesco, Russo Giulia, Candido Saverio, Pennisi Marzio, Cavalieri Salvatore, Motta Santo, McCubrey James A, Nicoletti Ferdinando, Libra Massimo

Abstract excerpt

BACKGROUND: Malignant melanoma is an aggressive tumor of the skin and seems to be resistant to current therapeutic approaches. Melanocytic transformation is thought to occur by sequential accumulation of genetic and molecular alterations able to activate the Ras/Raf/MEK/ERK (MAPK) and/or the PI3K/AKT (AKT) signalling pathways. Specifically, mutations of B-RAF activate MAPK pathway resulting in cell cycle...

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Identifiers

PMID: 27015094
DOI: 10.1371/journal.pone.0152104
PMCID: PMC4807832

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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