Article
The AKT-p21 phosphorylation signaling axis confers poor prognosis and dacarbazine resistance in melanoma
2025-08-07
Abstract excerpt
<title>Abstract</title> <p>Understanding the molecular mechanisms underlying melanoma metastasis and chemoresistance is vital to predict patients’ prognoses and develop more effective therapies. In this study, we investigated the role of p21 in melanoma progression and treatment resistance. Our findings reveal that increased gene and protein expression of p21 are strong predictors of poor prognosis in human melan...
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Identifiers and source
- Literature Corpus work
- 4713c385-1813-5b52-8636-fc0bb06e643d
- DOI
- 10.21203/rs.3.rs-7077835/v1