Article
PIK3CA-mutated melanoma cells rely on cooperative signaling through mTORC1/2 for sustained proliferation.
Pigment cell & melanoma research - 1 May 2017
Silva Jillian M, Deuker Marian M, Baguley Bruce C, McMahon Martin
Abstract excerpt
Malignant conversion of BRAF- or NRAS-mutated melanocytes into melanoma cells can be promoted by PI3'-lipid signaling. However, the mechanism by which PI3'-lipid signaling cooperates with mutationally activated BRAF or NRAS has not been adequately explored. Using human NRAS- or BRAF-mutated melan...
Topics
- Animals
- Carcinogenesis
- Cell Line, Tumor
- Cell Proliferation
- Class I Phosphatidylinositol 3-Kinases
- Drug Resistance, Neoplasm
- Humans
- Mechanistic Target of Rapamycin Complex 1
- Mechanistic Target of Rapamycin Complex 2
- Melanoma
- Mice, Nude
- Mitogen-Activated Protein Kinase Kinases
- Mutation
- Protein Kinase Inhibitors