Article
Enhancing the evaluation of PI3K inhibitors through 3D melanoma models.
Pigment cell & melanoma research - 1 May 2016
Shannan Batool, Chen Quan, Watters Andrea, Perego Michela, Krepler Clemens, Thombre Rakhee, Li Ling, Rajan Geena, Peterson Scott, Gimotty Phyllis A, Wilson Melissa, Nathanson Katherine L, Gangadhar Tara C, Schuchter Lynn M, Weeraratna Ashani T, Herlyn Meenhard, Vultur Adina
Abstract excerpt
Targeted therapies for mutant BRAF metastatic melanoma are effective but not curative due to acquisition of resistance. PI3K signaling is a common mediator of therapy resistance in melanoma; thus, the need for effective PI3K inhibitors is critical. However, testing PI3K inhibitors in adherent cultures is not always reflective of their potential in vivo. To emphasize this, we compared PI3K inhibitors of different...
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