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Article

miR-223-IGF-IR signalling in hypoxia- and load-induced right-ventricular failure: a novel therapeutic approach.

Cardiovascular research - 1 Aug 2016

Shi Lei, Kojonazarov Baktybek, Elgheznawy Amro, Popp Rüdiger, Dahal Bhola Kumar, Böhm Mario, Pullamsetti Soni Savai, Ghofrani Hossein-Ardeschir, Gödecke Axel, Jungmann Andreas, Katus Hugo A, Müller Oliver J, Schermuly Ralph T, Fisslthaler Beate, Seeger Werner, Fleming Ingrid

Abstract excerpt

AIMS: Pulmonary hypertension is a progressive disease with poor prognosis, characterized by pathological inward remodelling and loss of patency of the lung vasculature. The right ventricle is co-affected by pulmonary hypertension, which triggers events such as hypoxia and/or increased mechanical load. Initially the right ventricle responds with 'adaptive' hypertrophy, which is often rapidly followed by...

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Share to Heart Failure
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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Hypertension, Pulmonary

Share to Hypoxia

Share to Hypoxia-Inducible Factor 1, alpha Subunit

Share to Receptor, IGF Type 1

Share to Receptors, Somatomedin

Share to Ventricular Function, Right

Source

Identifiers

PMID: 27013635
DOI: 10.1093/cvr/cvw065

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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