Article
Common microRNA signatures in cardiac hypertrophic and atrophic remodeling induced by changes in hemodynamic load.
PloS one - 9 Dec 2010
El-Armouche Ali, Schwoerer Alexander Peter, Neuber Christiane, Emons Julius, Emmons Julius, Biermann Daniel, Christalla Thomas, Grundhoff Adam, Eschenhagen Thomas, Zimmermann Wolfram Hubertus, Ehmke Heimo
Abstract excerpt
BACKGROUND: Mechanical overload leads to cardiac hypertrophy and mechanical unloading to cardiac atrophy. Both conditions produce similar transcriptional changes including a re-expression of fetal genes, despite obvious differences in phenotype. MicroRNAs (miRNAs) are discussed as superordinate regulators of global gene networks acting mainly at the translational level. Here, we hypothesized that defined sets of...
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