Article
Common microRNA signatures in cardiac hypertrophic and atrophic remodeling induced by changes in hemodynamic load.
PloS one - 9 Dec 2010
El-Armouche Ali, Schwoerer Alexander Peter, Neuber Christiane, Emons Julius, Emmons Julius, Biermann Daniel, Christalla Thomas, Grundhoff Adam, Eschenhagen Thomas, Zimmermann Wolfram Hubertus, Ehmke Heimo
Abstract excerpt
BACKGROUND: Mechanical overload leads to cardiac hypertrophy and mechanical unloading to cardiac atrophy. Both conditions produce similar transcriptional changes including a re-expression of fetal genes, despite obvious differences in phenotype. MicroRNAs (miRNAs) are discussed as superordinate r...
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