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Article

JNK signaling regulates E-cadherin junctions in germline cysts and determines primordial follicle formation in mice

1 Jan 2016

Abstract excerpt

Physiologically, the size of the primordial follicle pool determines the reproductive lifespan of female mammals, while its establishment largely depends on a process of germline cyst breakdown during the perinatal period. The mechanisms regulating this process are poorly understood. Here we demonstrate that c-Jun amino-terminal kinase (JNK) signaling is crucial for germline cyst breakdown and primordial follicle...

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PMID: 27013242
DOI: 10.1242/dev.132175

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