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Notch2 is required in somatic cells for breakdown of ovarian germ-cell nests and formation of primordial follicles

13 Feb 2013

Abstract excerpt

BACKGROUND: In the mouse ovary, oocytes initially develop in clusters termed germ-cell nests. Shortly after birth, these germ-cell nests break apart, and the oocytes individually become surrounded by somatic granulosa cells to form primordial follicles. Notch signaling plays essential roles during oogenesis in Drosophila, and recent studies have suggested that Notch signaling also plays an essential role during...

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PMID: 23406467
DOI: 10.1186/1741-7007-11-13

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