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Article

Notch Signaling Regulates Ovarian Follicle Formation and Coordinates Follicular Growth

19 Feb 2014

Abstract excerpt

Ovarian follicles form through a process in which somatic pregranulosa cells encapsulate individual germ cells from germ cell syncytia. Complementary expression of the Notch ligand, Jagged1, in germ cells and the Notch receptor, Notch2, in pregranulosa cells suggests a role for Notch signaling in mediating cellular interactions during follicle assembly. Using a Notch reporter mouse, we demonstrate that Notch...

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PMID: 24552588
DOI: 10.1210/me.2013-1288

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