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Article

Reactive oxygen species stimulate mitochondrial allele segregation toward homoplasmy in human cells.

Molecular biology of the cell - 15 May 2016

Ling Feng, Niu Rong, Hatakeyama Hideyuki, Goto Yu-Ichi, Shibata Takehiko, Yoshida Minoru

Abstract excerpt

Mitochondria that contain a mixture of mutant and wild-type mitochondrial (mt) DNA copies are heteroplasmic. In humans, homoplasmy is restored during early oogenesis and reprogramming of somatic cells, but the mechanism of mt-allele segregation remains unknown. In budding yeast, homoplasmy is restored by head-to-tail concatemer formation in mother cells by reactive oxygen species (ROS)-induced rolling-circle...

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Identifiers

PMID: 27009201
DOI: 10.1091/mbc.E15-10-0690
PMCID: PMC4865324

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