KRAS mutation: should we test for it, and does it matter?

doi:10.1200/JCO.2012.43.0454

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Article

KRAS mutation: should we test for it, and does it matter?

Journal of clinical oncology : official journal of the American Society of Clinical Oncology - 10 Mar 2013

Roberts Patrick J, Stinchcombe Thomas E

Abstract excerpt

Lung cancer is the leading cause of cancer mortality in the United States and worldwide. Previously, lung cancer was simplistically divided into non-small-cell lung cancer (NSCLC) and small-cell lung cancer. However, in the last decade, we have gone from a simplistic binary system of classifying lung cancer to defining NSCLC on the basis of molecular subsets. KRAS mutations represent the most common molecular...

Topics

Antibodies, Monoclonal
Antineoplastic Agents
Biomarkers, Tumor
Carcinoma, Non-Small-Cell Lung
DNA Mutational Analysis
Drug Resistance, Neoplasm
ErbB Receptors
Genetic Techniques
Humans
Lung Neoplasms

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mutation

Predictive Value of Tests

Prognosis

Protein Kinase Inhibitors

Proto-Oncogene Proteins

Proto-Oncogene Proteins p21(ras)

ras Proteins

Source

Open in PubMed

Identifiers

PMID: 23401440
DOI: 10.1200/JCO.2012.43.0454

Genes

KRAS
EGFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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