Article
KRAS mutations in non-small cell lung cancer.
Proceedings of the American Thoracic Society - 15 Apr 2009
Riely Gregory J, Marks Jenifer, Pao William
Abstract excerpt
Some non-small cell lung cancers (NSCLCs) harbor a single specific mutated oncogene that is thought to be the primary genetic "driver" leading to cancer. The two most commonly mutated oncogenes in lung cancer encode for the epidermal growth factor receptor (EGFR) and KRAS. EGFR kinase domain mutations were only recently identified, but they have already been established in the clinic as valid predictors of...
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