Article
Detection of PIK3CA mutations, including a novel mutation of V344G in exon 4, in metastatic lung adenocarcinomas: A retrospective study of 115 FNA cases.
Cancer cytopathology - 1 Jul 2016
Allison Derek B, Lilo Mohammed T, Geddes Susan, Pallavajjalla Aparna, Askin Frederic, Gabrielson Edward, Zheng Gang, Li Qing Kay
Abstract excerpt
BACKGROUND: Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha (PIK3CA) mutations and amplification are detected in 1% of primary lung adenocarcinomas (ADCs) and in 38% of primary lung squamous cell carcinomas. Alterations of PIK3CA in metastatic non-small cell lung carcinoma (NSCLC), however, are still not fully understood. This study investigated PIK3CA alterations in metastatic ADCs and...
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