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Regulation of the Homeostatic Unfolded Protein Response in Diabetic Nephropathy

25 Mar 2022

Abstract excerpt

A growing body of scientific evidence indicates that protein homeostasis, also designated as proteostasis, is causatively linked to chronic diabetic nephropathy (DN). Experimental studies have demonstrated that the insulin signaling in podocytes maintain the homeostatic unfolded protein response (UPR). Insulin signaling via the insulin receptor non-canonically activates the spliced X-box binding protein-1...

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Share to Endoplasmic Reticulum Stress and Disease
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PMID: 35455399
DOI: 10.3390/ph15040401

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