Article
Individual and Familial Susceptibility to MPTP in a Common Marmoset Model for Parkinson's Disease.
Neuro-degenerative diseases - 1 Jan 2016
Franke Sigrid K, van Kesteren Ronald E, Hofman Sam, Wubben Jacqueline A M, Smit August B, Philippens Ingrid H C H M
Abstract excerpt
INTRODUCTION: Insight into susceptibility mechanisms underlying Parkinson's disease (PD) would aid the understanding of disease etiology, enable target finding and benefit the development of more refined disease-modifying strategies. METHODS: We used intermittent low-dose MPTP (0.5 mg/kg/week) injections in marmosets and measured multiple behavioral and neurochemical parameters. Genetically diverse monkeys from...
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