Article
Parkinson Disease Epidemiology, Pathology, Genetics, and Pathophysiology.
Clinics in geriatric medicine - 1 Feb 2020
Simon David K, Tanner Caroline M, Brundin Patrik
Abstract excerpt
Parkinson disease is a complex, age-related, neurodegenerative disease associated with dopamine deficiency and both motor and nonmotor deficits. Many environmental and genetic factors influence Parkinson disease risk, with different factors predominating in different patients. These factors converge on specific pathways, including mitochondrial dysfunction, oxidative stress, protein aggregation, impaired...
Topics
- Aged
- Genetic Predisposition to Disease
- Health Status Indicators
- Humans
- Metabolism
- Neuroimmunomodulation
- Parkinson Disease
- Patient Care Management