Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Mechanism of Germacradien-4-ol Synthase-Controlled Water Capture.

Biochemistry - 12 Apr 2016

Grundy Daniel J, Chen Mengbin, González Verónica, Leoni Stefano, Miller David J, Christianson David W, Allemann Rudolf K

Abstract excerpt

The sesquiterpene synthase germacradiene-4-ol synthase (GdolS) from Streptomyces citricolor is one of only a few known high-fidelity terpene synthases that convert farnesyl diphosphate (FDP) into a single hydroxylated product. Crystals of unliganded GdolS-E248A diffracted to 1.50 Å and revealed a typical class 1 sesquiterpene synthase fold with the active site in an open conformation. The metal binding motifs...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alkyl and Aryl Transferases
Share to Biocatalysis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Hydro-Lyases

Share to Hydroxylation

Share to Naphthols

Share to Polyisoprenyl Phosphates

Share to Sesquiterpenes

Share to Streptomyces

Source

Open in PubMed Open full text

Identifiers

PMID: 26998816
DOI: 10.1021/acs.biochem.6b00115
PMCID: PMC4829482

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mechanism of Germacradien-4-ol Synthase-Controlled Water Capture.PMID 26998816Read ↗

Cryo-EM Structure of the Cyclase Domain and Evaluation of Substrate Channeling in a Bifunctional Class II Terpene SynthaseSemantic proximity Read ↗

1.55Å-resolution structure of ent-copalyl diphosphate synthase and exploration of general acid function by site-directed mutagenesis.Semantic proximity Read ↗

Hedycaryol synthase in complex with nerolidol reveals terpene cyclase mechanism.Semantic proximity Read ↗

Mechanism-Based Post-Translational Modification and Inactivation in Terpene Synthases.Semantic proximity Read ↗

Systematic identification of functional residues of Artemisia annua amorpha-4,11-diene synthase.Semantic proximity Read ↗

Control of the 1,2-rearrangement process by oxidosqualene cyclases during triterpene biosynthesis.Semantic proximity Read ↗

Mutational analysis of white spruce (Picea glauca) ent-kaurene synthase (PgKS) reveals common and distinct mechanisms of conifer diterpene synthases of general and specialized metabolism.Semantic proximity Read ↗

The Radical SAM Enzyme BlsE Can Operate as a Dehydratase, Dehydrogenase, or Epimerase upon Mutation of a Single Active Site Serine Residue.Semantic proximity Read ↗

Oxidosqualene cyclase second-sphere residues profoundly influence the product profile.Semantic proximity Read ↗

Identification of dioxygenases required for Aspergillus development. Studies of products, stereochemistry, and the reaction mechanism.Semantic proximity Read ↗

Constructing tailored isoprenoid products by structure-guided modification of geranylgeranyl reductase.Semantic proximity Read ↗

Catalytic mechanism of the PrhA (V150L/A232S) double mutant involved in the fungal meroterpenoid biosynthetic pathway: a QM/MM study.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.