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Article

Identification of dioxygenases required for Aspergillus development. Studies of products, stereochemistry, and the reaction mechanism.

The Journal of biological chemistry - 30 Nov 2007

Garscha Ulrike, Jernerén Fredrik, Chung DaWoon, Keller Nancy P, Hamberg Mats, Oliw Ernst H

Abstract excerpt

Aspergillus sp. contain ppoA, ppoB, and ppoC genes, which code for fatty acid oxygenases with homology to fungal linoleate 7,8-diol synthases (7,8-LDS) and cyclooxygenases. Our objective was to identify these enzymes, as ppo gene replacements show critical developmental aberrancies in sporulation and pathogenicity in the human pathogen Aspergillus fumigatus and the genetic model Aspergillus nidulans. The PpoAs of...

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PMID: 17906293
DOI: 10.1074/jbc.M705366200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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