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Article

Control of the 1,2-rearrangement process by oxidosqualene cyclases during triterpene biosynthesis.

Organic & biomolecular chemistry - 14 Jul 2015

Takase Shohei, Saga Yusuke, Kurihara Nozomi, Naraki Shingo, Kuze Kenta, Nakata Genki, Araki Takeshi, Kushiro Tetsuo

Abstract excerpt

Oxidosqualene cyclases (OSCs) catalyze the cyclization of an acyclic substrate into various polycyclic triterpenes through a series of cation-π cyclization and 1,2-rearrangement processes. The mechanisms by which OSCs control the fate of intermediate carbocation to generate each specific triterpene product have not yet been determined. The formation of ubiquitous sterol precursors in plants, cycloartenol and...

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PMID: 26058429
DOI: 10.1039/c5ob00714c

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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