Article
Identification of a Bipotent Epithelial Progenitor Population in the Adult Thymus.
Cell reports - 29 Mar 2016
Ulyanchenko Svetlana, O'Neill Kathy E, Medley Tanya, Farley Alison M, Vaidya Harsh J, Cook Alistair M, Blair Natalie F, Blackburn C Clare
Abstract excerpt
Thymic epithelial cells (TECs) are critically required for T cell development, but the cellular mechanisms that maintain adult TECs are poorly understood. Here, we show that a previously unidentified subpopulation, EpCam(+)UEA1(-)Ly-51(+)PLET1(+)MHC class II(hi), which comprises <0.5% of adult TECs, contains bipotent TEC progenitors that can efficiently generate both cortical (c) TECs and medullary (m) TECs. No...
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