Article
Non-Epithelial Stromal Cells in Thymus Development and Function.
Frontiers in immunology - 1 Jan 2021
James Kieran D, Jenkinson William E, Anderson Graham
Abstract excerpt
The thymus supports T-cell development via specialized microenvironments that ensure a diverse, functional and self-tolerant T-cell population. These microenvironments are classically defined as distinct cortex and medulla regions that each contain specialized subsets of stromal cells. Extensive research on thymic epithelial cells (TEC) within the cortex and medulla has defined their essential roles during T-cell...
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