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Thymic epithelial cell fate and potency in early organogenesis assessed by single cell transcriptional and functional analysis

25 Jul 2023

Abstract excerpt

During development, cortical (c) and medullary (m) thymic epithelial cells (TEC) arise from the third pharyngeal pouch endoderm. Current models suggest that within the thymic primordium most TEC exist in a bipotent/common thymic epithelial progenitor cell (TEPC) state able to generate both cTEC and mTEC, at least until embryonic day 12.5 (E12.5) in the mouse. This view, however, is challenged by recent...

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PMID: 37559721
DOI: 10.3389/fimmu.2023.1202163

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