Article
Functional characterisation of ADIPOQ variants using individuals recruited by genotype.
Molecular and cellular endocrinology - 15 Jun 2016
Lee Benjamin P, Lloyd-Laney Henry O, Locke Jonathan M, McCulloch Laura J, Knight Bridget, Yaghootkar Hanieh, Cory Giles, Kos Katarina, Frayling Timothy M, Harries Lorna W
Abstract excerpt
Four non-coding GWAS variants in or near the ADIPOQ gene (rs17300539, rs17366653, rs3821799 and rs56354395) together explain 4% of the variation in circulating adiponectin. The functional basis for this is unknown. We tested the effect of these variants on ADIPOQ transcription, splicing and stability respectively in adipose tissue samples from participants recruited by rs17366653 genotype. Transcripts carrying...