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Article

Functional characterization of promoter variants of the adiponectin gene complemented by epidemiological data.

Diabetes - 1 Apr 2009

Laumen Helmut, Saningong Akuma D, Heid Iris M, Hess Jochen, Herder Christian, Claussnitzer Melina, Baumert Jens, Lamina Claudia, Rathmann Wolfgang, Sedlmeier Eva-Maria, Klopp Norman, Thorand Barbara, Wichmann H-Erich, Illig Thomas, Hauner Hans

Abstract excerpt

OBJECTIVE: Adiponectin (APM1, ACDC) is an adipocyte-derived protein with downregulated expression in obesity and insulin-resistant states. Several potentially regulatory single nucleotide polymorphisms (SNPs) within the APM1 gene promoter region have been associated with circulating adiponectin levels. None of them have been functionally characterized in adiponectin-expressing cells. Hence, we investigated three...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 19074982
DOI: 10.2337/db07-1646
PMCID: PMC2661577

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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