Article
Mutation in utp15 disrupts vascular patterning in a p53-dependent manner in zebrafish embryos.
PloS one - 1 Jan 2011
Mouillesseaux Kevin, Chen Jau-Nian
Abstract excerpt
BACKGROUND: Angiogenesis is the process by which the highly branched and functional vasculature arises from the major vessels, providing developing tissues with nutrients, oxygen, and removing metabolic waste. During embryogenesis, vascular patterning is dependent on a tightly regulated balance between pro- and anti-angiogenic signals, and failure of angiogenesis leads to embryonic lethality. Using the zebrafish...
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