Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Mammary tumor growth and metastasis are reduced in c-Kit mutant Sash mice.

Cancer medicine - 1 Jun 2016

He Licai, Zhu Zhenfeng, Chen Shang, Wang Yongping, Gu Haihua

Abstract excerpt

Besides its well-known function in allergic response, mast cell, one of the key immune cells present in tumor microenvironment, plays important roles in cancer progression. However, the functional role of mast cells in breast cancer development and metastasis is not well understood. To test the involvement of mast cells in breast cancer, we examined the effects of loss of mast cells on mammary tumor development...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Biopsy
Share to Cell Count
Share to Mammary Neoplasms, Animal

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mast Cells

Share to Mice, Transgenic

Share to Neoplasm Metastasis

Share to Proto-Oncogene Proteins c-kit

Share to Tumor Burden

Source

Open in PubMed Open full text

Identifiers

PMID: 26992445
DOI: 10.1002/cam4.696
PMCID: PMC4924387

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mammary tumor growth and metastasis are reduced in c-Kit mutant Sash mice.PMID 26992445Read ↗

Mast cell-deficient Kit(W-sh) "Sash" mutant mice display aberrant myelopoiesis leading to the accumulation of splenocytes that act as myeloid-derived suppressor cells.Semantic proximity Read ↗

Mast cell-deficient W-sash c-kit mutant Kit W-sh/W-sh mice as a model for investigating mast cell biology in vivo.Semantic proximity Read ↗

Mastocytosis in mice expressing human Kit receptor with the activating Asp816Val mutationSemantic proximity Read ↗

A protective role of mast cells in intestinal tumorigenesisSemantic proximity Read ↗

Mast cell hyperplasia, B-cell malignancy, and intestinal inflammation in mice with conditional expression of a constitutively active kit.Semantic proximity Read ↗

Molecular genetics and development of mast cells: implications for molecular medicine.Semantic proximity Read ↗

Mast cell deficient mice and rats with mutations of the c-kit protooncogene.Semantic proximity Read ↗

A new human mast cell line expressing a functional IgE receptor converts to tumorigenic growth by KIT D816V transfectionSemantic proximity Read ↗

Characterization of various types of mast cells derived from model mice of familial gastrointestinal stromal tumors with KIT-Asp818Tyr mutation.Semantic proximity Read ↗

Mast cells promote melanoma colonization of lungs.Semantic proximity Read ↗

Unique effects of KIT D816V in BaF3 cells: induction of cluster formation, histamine synthesis, and early mast cell differentiation antigens.Semantic proximity Read ↗

Cre/loxP-based mouse models of mast cell deficiency and mast cell-specific gene inactivation.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.