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Article

Dopamine D2 gene expression interacts with environmental enrichment to impact lifespan and behavior.

Oncotarget - 12 Apr 2016

Thanos Panayotis K, Hamilton John, O'Rourke Joseph R, Napoli Anthony, Febo Marcelo, Volkow Nora D, Blum Kenneth, Gold Mark

Abstract excerpt

Aging produces cellular, molecular, and behavioral changes affecting many areas of the brain. The dopamine (DA) system is known to be vulnerable to the effects of aging, which regulate behavioral functions such as locomotor activity, body weight, and reward and cognition. In particular, age-related DA D2 receptor (D2R) changes have been of particular interest given its relationship with addiction and other...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 26992232
DOI: 10.18632/oncotarget.8088
PMCID: PMC4991369

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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