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Article

DRD4 genotype predicts longevity in mouse and human.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 2 Jan 2013

Grady Deborah L, Thanos Panayotis K, Corrada Maria M, Barnett Jeffrey C, Ciobanu Valentina, Shustarovich Diana, Napoli Anthony, Moyzis Alexandra G, Grandy David, Rubinstein Marcelo, Wang Gene-Jack, Kawas Claudia H, Chen Chuansheng, Dong Qi, Wang Eric, Volkow Nora D, Moyzis Robert K

Abstract excerpt

Longevity is influenced by genetic and environmental factors. The brain's dopamine system may be particularly relevant, since it modulates traits (e.g., sensitivity to reward, incentive motivation, sustained effort) that impact behavioral responses to the environment. In particular, the dopamine D4 receptor (DRD4) has been shown to moderate the impact of environments on behavior and health. We tested the...

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Identifiers

PMID: 23283341
DOI: 10.1523/JNEUROSCI.3515-12.2013
PMCID: PMC3710129

Genes

DRD4

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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