Article
Higher proportion of viral basal core promoter mutant increases the risk of liver cirrhosis in hepatitis B carriers.
Gut - 1 Feb 2015
Tseng Tai-Chung, Liu Chun-Jen, Yang Hung-Chih, Chen Chi-Ling, Yang Wan-Ting, Tsai Cheng-Shiue, Kuo Stephanie Fang-Tzu, Verbree Femke Carolien, Su Tung-Hung, Wang Chia-Chi, Liu Chen-Hua, Chen Pei-Jer, Chen Ding-Shinn, Kao Jia-Horng
Abstract excerpt
BACKGROUND AND OBJECTIVE: Precore (PC) variant (G1896A) and basal core promoter (BCP) variant (A1762T/G1764A) of HBV are associated with risk of hepatocellular carcinoma in HBV carriers. However, little is known about their impact on the adverse outcomes of hepatitis B e antigen (HBeAg)-negative hepatitis and liver cirrhosis. METHODS: 251 spontaneous HBeAg seroconverters who had genotype B or C infection and...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.