Article
Glutamate receptor metabotropic 7 is cis-regulated in the mouse brain and modulates alcohol drinking.
Genomics - 1 Dec 2007
Vadasz Csaba, Saito Mariko, Gyetvai Beatrix M, Oros Melinda, Szakall Istvan, Kovacs Krisztina M, Prasad Vidudala V T S, Toth Reka
Abstract excerpt
Alcoholism is a heritable disease that afflicts about 8% of the adult population. Its development and symptoms, such as craving, loss of control, physical dependence, and tolerance, have been linked to changes in mesolimbic, mesocortical neurotransmitter systems utilizing biogenic amines, GABA, and glutamate. Identification of genes predisposing to alcoholism, or to alcohol-related behaviors in animal models, has...
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