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Article

Mutations in the Schmallenberg Virus Gc Glycoprotein Facilitate Cellular Protein Synthesis Shutoff and Restore Pathogenicity of NSs Deletion Mutants in Mice.

Journal of virology - 1 Jun 2016

Varela Mariana, Pinto Rute Maria, Caporale Marco, Piras Ilaria M, Taggart Aislynn, Seehusen Frauke, Hahn Kerstin, Janowicz Anna, de Souza William Marciel, Baumgärtner Wolfgang, Shi Xiaohong, Palmarini Massimo

Abstract excerpt

UNLABELLED: Serial passage of viruses in cell culture has been traditionally used to attenuate virulence and identify determinants of viral pathogenesis. In a previous study, we found that a strain of Schmallenberg virus (SBV) serially passaged in tissue culture (termed SBVp32) unexpectedly displayed increased pathogenicity in suckling mice compared to wild-type SBV. In this study, we mapped the determinants of...

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Identifiers

PMID: 26984728
DOI: 10.1128/JVI.00424-16
PMCID: PMC4934738

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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