Article
Runs of homozygosity and inbreeding in thyroid cancer.
BMC cancer - 16 Mar 2016
Thomsen Hauke, Chen Bowang, Figlioli Gisella, Elisei Rossella, Romei Cristina, Cipollini Monica, Cristaudo Alfonso, Bambi Franco, Hoffmann Per, Herms Stefan, Landi Stefano, Hemminki Kari, Gemignani Federica, Försti Asta
Abstract excerpt
BACKGROUND: Genome-wide association studies (GWASs) have identified several single-nucleotide polymorphisms (SNPs) influencing the risk of thyroid cancer (TC). Most cancer predisposition genes identified through GWASs function in a co-dominant manner, and studies have not found evidence for recessively functioning disease loci in TC. Our study examines whether homozygosity is associated with an increased risk of...
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