Article
Thyroid cancer susceptibility polymorphisms: confirmation of loci on chromosomes 9q22 and 14q13, validation of a recessive 8q24 locus and failure to replicate a locus on 5q24.
Journal of medical genetics - 1 Mar 2012
Jones Angela M, Howarth Kimberley M, Martin Lynn, Gorman Maggie, Mihai Radu, Moss Laura, Auton Adam, Lemon Catherine, Mehanna Hisham, Mohan Hosahalli, Clarke Susan E M, Wadsley Jonathan, Macias Elena, Coatesworth Andrew, Beasley Matthew, Roques Tom, Martin Craig, Ryan Paul, Gerrard Georgina, Power Danielle, Bremmer Caroline, Tomlinson Ian, Carvajal-Carmona Luis G
Abstract excerpt
Five single nucleotide polymorphisms (SNPs) associated with thyroid cancer (TC) risk have been reported: rs2910164 (5q24); rs6983267 (8q24); rs965513 and rs1867277 (9q22); and rs944289 (14q13). Most of these associations have not been replicated in independent populations and the combined effects of the SNPs on risk have not been examined. This study genotyped the five TC SNPs in 781 patients recruited through...