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Article

DNA haplotype analysis of CAG repeat in Taiwanese Huntington's disease patients.

European neurology - 1 Jan 2004

Wang C K, Wu Y R, Hwu W L, Chen C M, Ro L S, Chen S T, Gwinn-Hardy K, Yang C C, Wu R M, Chen T F, Wang H C, Chao M C, Chiu M J, Lu C J, Lee-Chen G J

Abstract excerpt

We studied the expanded CAG repeat and adjacent CCG repeat in 53 Huntington's disease (HD) patients and 172 unrelated normal subjects matched to the patients for ethnic origin. The range of the CAG repeat varied from 38 to 109 in the HD patients and from 10 to 29 in the control group. A significant negative correlation was found between the age at onset and the CAG expansion, with no significant influence of the...

Topics

Alleles
Case-Control Studies
Chi-Square Distribution
Chromosomes
Family Health
Haplotypes
Humans
Huntington Disease
Linkage Disequilibrium
Mutation
Polymerase Chain Reaction

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Taiwan

Trinucleotide Repeats

Source

Identifiers

PMID: 15273431
DOI: 10.1159/000079938

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