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Article

CAG repeat variants in the POLG1 gene encoding mtDNA polymerase-gamma and risk of breast cancer in African-American women.

PloS one - 1 Jan 2012

Azrak Sami, Ayyasamy Vanniarajan, Zirpoli Gary, Ambrosone Christine, Bandera Elisa V, Bovbjerg Dana H, Jandorf Lina, Ciupak Gregory, Davis Warren, Pawlish Karen S, Liang Ping, Singh Keshav

Abstract excerpt

The DNA polymerase-gamma (POLG) gene, which encodes the catalytic subunit of enzyme responsible for directing mitochondrial DNA replication in humans, contains a polyglutamine tract encoded by CAG repeats of varying length. The length of the CAG repeat has been associated with the risk of testicular cancer, and other genomic variants that impact mitochondrial function have been linked to breast cancer risk in...

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Source

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Identifiers

PMID: 22276120
DOI: 10.1371/journal.pone.0029548
PMCID: PMC3262786

Genes

POLG

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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