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Article

Immunohistochemical detection of NRAS(Q61R) protein in follicular-patterned thyroid tumors.

Human pathology - 1 Jul 2016

Oishi Naoki, Kondo Tetsuo, Vuong Huy Gia, Nakazawa Tadao, Mochizuki Kunio, Kasai Kazunari, Inoue Tomohiro, Tahara Ippei, Hirokawa Mitsuyoshi, Miyauchi Akira, Katoh Ryohei

Abstract excerpt

The NRAS(A182G) mutation, which results in the NRAS(Q61R) protein, is a major driver mutation in follicular-patterned thyroid neoplasms. Although new immunohistochemistry (IHC) for NRAS(Q61R) is now available, its sensitivity, specificity, and diagnostic utility for thyroid tumors are not yet established. We performed IHC for NRAS(Q61R) and direct sequencing for NRAS codon 61 in 4 thyroid cancer-derived cell...

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Source

Identifiers

PMID: 26980032
DOI: 10.1016/j.humpath.2016.02.008

Genes

NRAS
BRAF

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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