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Article

The Molecular Heterogeneity of NRAS Variants in Thyroid Nodules.

Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery - 1 Aug 2026

Ravin Emma De, Alshalalfa Mohammed, Jiang Ruochen, Hao Yangyang, Klopper Joshua P, Cottrill Elizabeth

Abstract excerpt

OBJECTIVE: NRAS variants are the most common mutations in thyroid nodules with (B)ethesda III/IV cytology. This study aims to characterize co-occurring variants, molecular signatures, and hallmarks of cancer pathways in nodules with NRAS variants. STUDY DESIGN: Retrospective database analysis. METHODS: The database of nodules sent for Afirma GSC testing was analyzed for the most common NRAS hotspot mutations,...

Topics

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GSC gene
MYC gene
TERT gene
GTP Phosphohydrolases
Membrane Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 42307992
DOI: 10.1002/ohn.70298
PMCID: PMC13418077

Genes

NRAS
TERT
GSC
BRAF
EIF1AX
MYC

Variants

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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