Serotonin and the Brain's Rich Club-Association Between Molecular Genetic Variation on the TPH2 Gene and the Structural Connectome.

doi:10.1093/cercor/bhw059

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Serotonin and the Brain's Rich Club-Association Between Molecular Genetic Variation on the TPH2 Gene and the Structural Connectome.

Cerebral cortex (New York, N.Y. : 1991) - 1 Mar 2017

Markett Sebastian, de Reus Marcel A, Reuter Martin, Montag Christian, Weber Bernd, Schoene-Bake Jan-Christoph, van den Heuvel Martijn P

Abstract excerpt

The rich club comprises a densely mutually connected set of hub regions in the brain, thought to serve as a processing and integration core. We assessed the impact of normal variation of the tryptophane hydroxylase 2 gene's promotor region (TPH2 rs4570625) on structural connectivity of the rich club pathways by means of a candidate gene association design. Tryptophane hydroxylase 2 (TPH2) is a rate-limiting...

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PMID: 26975194
DOI: 10.1093/cercor/bhw059

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TPH2

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