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Article

Unfolded Protein Response in Drosophila: Why Another Model Can Make It Fly

1 Apr 2007

Abstract excerpt

The unfolded protein response (UPR) is an intracellular signaling pathway that is activated in response to stress in the endoplasmic reticulum (ER). UPR can effectively cope with stress by reducing the amount of misfolded protein overload in this subcellular organelle. Significantly, ER-stress is associated with various neurodegenerative disorders, diabetes and cancer, where UPR affects the course of disease...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 17387279
DOI: 10.4161/cc.6.7.4064

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